DSIP
Delta Sleep-Inducing Peptide
sleep
stress
anxiety
mental fatigue
training recovery
A nine-amino-acid peptide pulled out of rabbit blood during induced deep sleep in 1977. Named for what it was found in, not for what it reliably does — the human sleep trials that followed were small and split.
Goal profile
MOOD
3/8 axes
RECOVERY
2/6 axes
LONGEVITY
1/7 axes
BRAIN
1/8 axes
Evidence
1977
first described
118
indexed studies
How strong the evidence is
Early human data
Small human studies exist and some are controlled, but they are from the 1980s, run on a few dozen people each, and they disagree. The strongest results are in chronic pain and withdrawal, not sleep. Nobody has repeated the sleep work at modern scale.
Highest study design
open-label human use
Human studies
5
Replication
several groups, one country
Regulatory status
not approved anywhere
Last reviewed
2026-09-20
The bar is derived from these five facts, not set by hand. Human study counts follow the weekly PubMed refresh; the rest change only when a trial is published or a regulator acts.
How strong the effect is
strength 2 of 5 · weight 0.31
Noticeable but modest
Small human studies from the 1980s, and they disagree. Some people report deeper nights; many report nothing.
What's unique
It is not a sedative. Nothing forces you under — what is described is the architecture of the night settling into shape, which is why people who take it expecting a knockout report that it does nothing.
Unexpected positive evidence
Its strongest human results came from studies of chronic pain and opioid withdrawal, not sleep. The sleep evidence, which the name promises, is the weakest part of the file.
Benefits
the gap between lying down and falling asleep gets shorter
Sleep · immediate
fewer wake-ups in the second half of the night
Sleep · immediate
the night keeps its shape instead of being knocked out — the distinction the original researchers cared about
Sleep · immediate
stress reactivity comes down without sedation attached to it
Stress · from week 2
less mental fatigue in the first hour after waking
Mental fatigue · from week 3
lower anxiety scores in the same small trials that measured pain
Anxiety · from week 3
overnight recovery from training, claimed through deeper sleep rather than any direct action on muscle
Training recovery · from week 5
Timeline
Nights 1–3
Usually nothing dramatic, and that trips people up. There is no sedative pull, no heaviness coming on. What a few notice is that the gap between lying down and losing the thread got shorter.
Nights 3–10
The window where the reports cluster: fewer wake-ups in the second half of the night, and mornings that start without the first hour being a write-off. Dosed too late, this is also where thick mornings show up — move it earlier rather than lowering the dose.
Weeks 2–4
Whatever changed tends to hold rather than build. Nothing accumulates in the blood, so there is no ramp to wait for — by the end of week two you already know if this is doing anything for you.
After the course
No rebound insomnia described, no withdrawal. Sleep drifts back to its own baseline over a week or so. The honest read: if four weeks changed nothing, a fifth will not.
Risks
Short-term
Injection-site reactions. A heavy head the next morning if dosed too late in the night.
Long-term
Almost no modern data. The human work is from the 1980s, small, and never replicated at scale.
Tolerance & withdrawal
Cleared from blood in minutes, so nothing accumulates. Short courses are still the published pattern.
Dosing
Dose
100–400 mcg
Most published human work sits near 200 mcg. Above 400 nothing improves; mornings just get heavier.
Route
Subcutaneous — abdomen
A small volume into the belly. Rotate sites across the course.
Timing
30–60 minutes before bed
It clears the blood in minutes, so the window is narrow. Too early and it is gone by bedtime; too late and the next morning feels thick.
Frequency
Every night of the course
Nightly. Nothing accumulates, so there is no reason to skip nights.
Cycle
2–4 weeks on, then off
Short courses. Long continuous use has never been studied in anyone.
Duration
Four weeks at most
Four weeks is the ceiling in published protocols. After that you are measuring habit, not the peptide.
Forms
injectable
~100%
+ Full dose delivered; nothing lost to first-pass
− Daily needles, sites, sharps disposal
Refrigerate 2–8 °C after reconstitution
Sources
118 indexed papers in the source catalog snapshot; not a live PubMed count
Catalog evidence category: theoretical. This is an editorial classification, not a clinical review.
Community anecdotes do not establish safety or efficacy.
Primary regulatory sources are linked below; clinical literature has not been independently reviewed for this FAQ.
FAQ
DSIP (Delta Sleep-Inducing Peptide) is a nonapeptide (9 amino acids). The HEIVE catalog describes it as: A nine-amino-acid peptide pulled out of rabbit blood during induced deep sleep in 1977. Named for what it was found in, not for what it reliably does — the human sleep trials that followed were small and split. It is also known as Delta sleep-inducing peptide and Delta-sleep peptide.
Regulatory sources checked: . Source verification only; no clinician review is claimed.