Selank

Tuftsin analogue
anxiety
stress
emotional balance
sleep
focus
mental clarity
low mood
social connection
burnout
memory
neuroprotection
motivation
immune balance
An anxiolytic peptide developed alongside Semax, studied for generalised anxiety without sedation.
Goal profile
MOOD
8/8 axes
BRAIN
4/8 axes
IMMUNITY
1/4 axes
RECOVERY
1/6 axes
LONGEVITY
1/7 axes

Evidence

1990
first described
76
indexed studies
How strong the evidence is
Early human data
Randomised anxiety trials against benzodiazepines, registered in Russia. Same limitation as Semax: real trials, one jurisdiction.
Highest study design
randomised human trials
Human studies
22
Replication
several groups, one country
Regulatory status
approved outside the US and EU
Last reviewed
2026-08-14
The bar is derived from these five facts, not set by hand. Human study counts follow the weekly PubMed refresh; the rest change only when a trial is published or a regulator acts.
How strong the effect is
strength 3 of 5 · weight 0.56
Changes how you feel
Comparable to benzodiazepines on anxiety.
What's unique
Anxiolysis without sedation or the memory cost that comes with benzodiazepines.
Unexpected positive evidence
Immune markers shifted in trials that were only measuring anxiety scores.

Benefits

anxiolysis without sedation, dependence, or cognitive dulling
Anxiety · immediate
stabilisation of GABAergic and serotonergic tone under chronic stress
Low mood · from week 3
sharper attention and working memory when anxiety is the limiting factor
Anxiety · immediate
immune modulation through its tuftsin backbone and interleukin balance
Immune balance · from week 8
faster sleep onset without altering sleep architecture
Anxiety · immediate
smoother withdrawal from benzodiazepines and alcohol in clinical use
Anxiety · immediate

Timeline

Days 1–7
Anxiety softens within hours of the first doses, without sedation. Racing thoughts quieten, and physical tension — jaw, shoulders, stomach — eases.
Weeks 2–3
The calm becomes a baseline rather than a dose-by-dose effect. Sleep onset improves because the mind stops running. Social situations feel less effortful.
Weeks 3–6
Stable window. Stress no longer escalates as quickly, and recovery after a stressful day is faster. Cognitive sharpness is preserved throughout — this is the point of it.
Post-cycle
Anxiolysis fades over days. No rebound anxiety is described in the clinical record, which separates it from benzodiazepines.

Risks

Short-term
Some users report flatness rather than calm.
Long-term
No dependency observed in the Russian clinical record.
Tolerance & withdrawal
No tolerance described across 14-day courses.

Dosing

Dose
250–1,000 mcg
250–500 mcg covers most use; the anxiolytic effect plateaus early.
Route
Subcutaneous — abdomen
A small volume into the belly, rotating sites across the course.
Timing
Morning, or before a demanding day
An hour before the thing you are dreading is the practical use; the daily morning shot is the maintenance version.
Frequency
Daily, or 5 on / 2 off
People run it daily through a rough stretch and drop to 5/2 once it becomes routine.
Cycle
3–6 weeks
Short blocks. It works best before the body has adapted to it.
Duration
Short courses
The effect dulls with continuous use, so most treat it as a tool for a period rather than a habit.

Forms

injectable
~100%
+ Full dose delivered; nothing lost to first-pass
− Daily needles, sites, sharps disposal
Refrigerate 2–8 °C after reconstitution
nasal
Product-specific
+ A needle-free route listed in the source catalog
− Absorption and safety cannot be inferred from the injectable form
Follow the specific product storage instructions

Nasal forms are listed in the source catalog; this does not establish approval, efficacy or equivalent absorption. HEIVE injection calculations do not apply to nasal forms.

Sources

76 indexed papers in the source catalog snapshot; not a live PubMed count
Catalog evidence category: known. This is an editorial classification, not a clinical review.
Community anecdotes do not establish safety or efficacy.
Primary regulatory sources are linked below; clinical literature has not been independently reviewed for this FAQ.
FAQ

Selank (Tuftsin analogue) is a heptapeptide. The HEIVE catalog describes it as: An anxiolytic peptide developed alongside Semax, studied for generalised anxiety without sedation.

Regulatory sources checked: . Source verification only; no clinician review is claimed.

Goals

Protocols with this peptide

Educational reference. Figures are illustrative and not a prescription, protocol, or medical advice.

Open in HEIVE