Tirzepatide
GIP/GLP-1 dual agonist
appetite
glycemic control
body recomposition
metabolic health
fat distribution
cardiovascular health
keeping the result
healthspan
Two incretin receptors instead of one. Licensed for type 2 diabetes and for obesity, with head-to-head data against semaglutide behind it.
Goal profile
WEIGHT
5/5 axes
LONGEVITY
3/7 axes
PERFORMANCE
1/4 axes
Evidence
2018
first described
2,353
indexed studies
How strong the evidence is
Licensed medicine
Beat semaglutide head to head in a properly powered trial. Four years on the market — the common problems are known, the rare ones are not yet.
Highest study design
registration trials
Human studies
186
Replication
independent international
Regulatory status
FDA or EMA approval
Last reviewed
2026-08-14
The bar is derived from these five facts, not set by hand. Human study counts follow the weekly PubMed refresh; the rest change only when a trial is published or a regulator acts.
How strong the effect is
strength 4 of 5 · weight 0.86
Changes the result
15–22% of body weight, and it beat semaglutide head-to-head.
What's unique
The GIP arm appears to blunt the nausea that limits pure GLP-1 dosing.
Unexpected positive evidence
Sleep-apnoea severity fell far enough in trials to earn its own licensed indication.
Benefits
dual GIP and GLP-1 activation for stronger appetite control than either alone
Appetite · immediate
sustained 15–22% body-weight reduction
Appetite · immediate
better glycaemic control at a lower nausea burden than pure GLP-1 dosing
Glycemic control · from week 3
improved insulin sensitivity and beta-cell response
Glycemic control · from week 3
reduced sleep-apnoea severity and easier night-time breathing
Appetite · immediate
lipid and blood-pressure markers improve alongside weight loss
Cardiovascular health · from week 12
Timeline
Weeks 1–4
Appetite suppression arrives fast and is usually stronger than GLP-1 alone. Nausea tends to be milder than expected — the GIP arm appears to blunt it.
Weeks 4–12
Consistent weekly loss through escalation. Cravings stay low rather than fluctuating. Sleep quality often improves in parallel with weight.
Weeks 12–72
The trial window. Loss continues far longer than most expect before plateauing; the largest gains in the trials came after week 24.
Post-cycle
Appetite returns within weeks and regain is well documented. Nothing about the exit differs from the other incretins.
Risks
Short-term
Nausea, diarrhoea, constipation. Worst in the fortnight after each step up.
Long-term
Muscle loss alongside fat; gallbladder events; pancreatitis at trial rates.
Tolerance & withdrawal
No tolerance. Regain on discontinuation is well documented.
Dosing
Dose
2.5–15 mg per week
Most stop climbing at 10 mg; 15 mg is for people whose loss has stalled.
Route
Subcutaneous — abdomen, thigh or upper arm
Rotate between the three areas week to week — the same spot every time builds hard tissue.
Timing
Any time of day, same day each week
Anchor the day to something fixed; the hour makes no measurable difference.
Frequency
Once a week
The half-life covers a full week, so splitting doses adds injections without adding effect.
Cycle
Titrate every 4 weeks, then hold
Four-week steps up, then hold. The dose you tolerate is the dose you keep.
Duration
Open-ended
Most people hold at whatever dose they tolerate rather than pushing to the maximum.
Forms
injectable
~100%
+ Full dose delivered; nothing lost to first-pass
− Daily needles, sites, sharps disposal
Refrigerate 2–8 °C after reconstitution
Sources
2,353 indexed papers in the source catalog snapshot; not a live PubMed count
Catalog evidence category: known. This is an editorial classification, not a clinical review.
Community anecdotes do not establish safety or efficacy.
Primary regulatory sources are linked below; clinical literature has not been independently reviewed for this FAQ.
FAQ
Tirzepatide (GIP/GLP-1 dual agonist) is a dual agonist (39 amino acids). The HEIVE catalog describes it as: Two incretin receptors instead of one. Licensed for type 2 diabetes and for obesity, with head-to-head data against semaglutide behind it. It is also known as Mounjaro and Zepbound.
Regulatory sources checked: . Source verification only; no clinician review is claimed.