Tesamorelin
GHRH analogue
fat distribution
body recomposition
keeping the result
metabolic health
glycemic control
cardiovascular health
muscle
FDA-approved for HIV-associated lipodystrophy; the only item here with visceral-fat outcomes in registration trials.
Goal profile
WEIGHT
4/5 axes
PERFORMANCE
2/4 axes
LONGEVITY
2/7 axes
Evidence
2010
first described
124
indexed studies
How strong the evidence is
Licensed medicine
Two full registration trials for visceral fat in HIV lipodystrophy, and a live FDA approval. Liver fat and cognition have real data but no approval.
Highest study design
registration trials
Human studies
26
Replication
independent international
Regulatory status
FDA or EMA approval
Last reviewed
2026-08-14
The bar is derived from these five facts, not set by hand. Human study counts follow the weekly PubMed refresh; the rest change only when a trial is published or a regulator acts.
How strong the effect is
strength 3 of 5 · weight 0.58
Changes how you feel
Visceral fat in lipodystrophy, with a moderate effect.
What's unique
The only growth-hormone peptide here with a registration trial and a licensed indication behind it.
Unexpected positive evidence
Cognitive scores improved in older adults in a trial powered for body composition.
Benefits
clinically proven reduction of visceral adipose tissue
Fat distribution · from week 4
improved lipid profile and triglyceride clearance
Glycemic control · from week 8
reduced liver fat and improved liver enzymes
Fat distribution · from week 4
lean mass preserved while abdominal fat falls
Keeping the result · from week 6
IGF-1 restored inside physiological range with your own axis intact
Fat distribution · from week 4
sharper cognition in older adults alongside the fat loss
Fat distribution · from week 4
Timeline
Weeks 1–2
Nothing visible. Some report better sleep and mild fluid retention in hands or feet as growth hormone rises.
Weeks 2–8
Visceral fat begins to fall measurably. Waist circumference is the honest metric here — scale weight often barely moves, which is the point.
Weeks 8–26
The trial window. Deep abdominal fat reduction continues throughout; this is the one peptide here with licensed evidence for that specific job.
Post-cycle
Visceral fat returns over months if diet and activity are unchanged. Trial data show regain when treatment stops, so plan an exit.
Risks
Short-term
Joint aches, oedema, injection-site reactions — all documented at trial frequencies.
Long-term
Glucose intolerance in a minority. Monitored with HbA1c in clinical use.
Tolerance & withdrawal
Continuous daily dosing is the licensed pattern; no cycling required.
Dosing
Dose
1–2 mg per injection
2 mg is the trial dose; 1 mg is a cost compromise, not a lower-risk one.
Route
Subcutaneous — abdomen, rotating quadrants
Abdomen, rotating quadrants — daily shots in one spot bruise.
Timing
Evening, before bed
Bedtime is what the registration trials used, and there is no reason to deviate.
Frequency
Daily
Missing a day costs little; missing a week resets the progress you paid months for.
Cycle
12–26 weeks
Visceral fat moves on a scale of months, so three to six is realistic.
Duration
Months, not weeks
The visceral-fat data came from trials that ran six months or more, so short runs prove nothing.
Forms
injectable
~100%
+ Full dose delivered; nothing lost to first-pass
− Daily needles, sites, sharps disposal
Refrigerate 2–8 °C after reconstitution
Sources
124 indexed papers in the source catalog snapshot; not a live PubMed count
Catalog evidence category: known. This is an editorial classification, not a clinical review.
Community anecdotes do not establish safety or efficacy.
Primary regulatory sources are linked below; clinical literature has not been independently reviewed for this FAQ.
FAQ
Tesamorelin (GHRH analogue) is a synthetic GHRH (44 amino acids). The HEIVE catalog describes it as: FDA-approved for HIV-associated lipodystrophy; the only item here with visceral-fat outcomes in registration trials. It is also known as Egrifta.
Regulatory sources checked: . Source verification only; no clinician review is claimed.