Thymosin α-1

Thymalfasin
immune balance
infection recovery
infection defense
inflammation
immune ageing
fatigue
healthspan
Thymosin alpha-1 is listed in FDA compounding safety information. Country-specific registrations are not verified here.
Goal profile
IMMUNITY
4/4 axes
ENERGY
1/5 axes
RECOVERY
1/6 axes
LONGEVITY
1/7 axes

Evidence

1977
first described
958
indexed studies
How strong the evidence is
Controlled human trials
Licensed in more than thirty countries for hepatitis and sepsis, with trials from several independent groups. Never reviewed by the FDA or EMA.
Highest study design
randomised human trials
Human studies
96
Replication
independent international
Regulatory status
approved outside the US and EU
Last reviewed
2026-08-14
The bar is derived from these five facts, not set by hand. Human study counts follow the weekly PubMed refresh; the rest change only when a trial is published or a regulator acts.
How strong the effect is
strength 4 of 5 · weight 0.76
Changes the result
A survival benefit in severe infection.
What's unique
Licensed in over 30 countries, which puts it in a different regulatory universe from most of this list.
Unexpected positive evidence
Sepsis mortality trials found benefit at doses chosen for hepatitis.

Benefits

T-cell maturation and restored balance between Th1 and Th2 responses
Immune balance · from week 2
antiviral support in chronic hepatitis B and C
Infection defense · from week 3
better vaccine response and immune competence in older adults
Immune ageing · from week 6
better survival odds in severe infection
Immune balance · from week 5
adjunctive use in oncology against chemotherapy immunosuppression
Immune balance · from week 2
faster clearance of recurring infections
Infection defense · from week 3

Timeline

Days 1–14
Little is felt directly. In an active infection, recovery is faster and symptoms are shorter — that is the intended signal, not a sensation.
Weeks 2–6
Immune markers shift: T-cell counts and function improve. Practically, this shows up as catching less of what goes around rather than feeling different.
Weeks 6–12
The clinical window used in hepatitis and sepsis trials. Benefits accumulate quietly; the honest measure is how often you get ill, not how you feel today.
Post-cycle
Immune parameters drift back over one to two months. Seasonal courses are the common pattern rather than continuous use.

Risks

Short-term
Injection-site reaction; brief flu-like feeling.
Long-term
Autoimmune flare risk in predisposed people — it modulates rather than suppresses.
Tolerance & withdrawal
Given in defined courses, not continuously.

Dosing

Dose
1.6 mg per injection
1.6 mg is the licensed amount and nearly everyone uses exactly that.
Route
Subcutaneous — abdomen
A belly shot; nobody reports a difference between sites.
Timing
Any time of day
No timing evidence exists — fold it into whatever else you inject that day.
Frequency
2× a week, daily during an active infection
Twice weekly for maintenance; daily during an active infection is the clinical pattern.
Cycle
4–8 weeks, or around illness
Most run it seasonally or around a specific illness rather than continuously.
Duration
Seasonal courses
Used as a seasonal block or around infection, not as a year-round immune supplement.

Forms

injectable
~100%
+ Full dose delivered; nothing lost to first-pass
− Daily needles, sites, sharps disposal
Refrigerate 2–8 °C after reconstitution

Sources

958 indexed papers in the source catalog snapshot; not a live PubMed count
Catalog evidence category: known. This is an editorial classification, not a clinical review.
Community anecdotes do not establish safety or efficacy.
Primary regulatory sources are linked below; clinical literature has not been independently reviewed for this FAQ.
FAQ

Thymosin α-1 (Thymalfasin) is a peptide (28 amino acids). The HEIVE catalog describes it as: Thymosin alpha-1 is listed in FDA compounding safety information. Country-specific registrations are not verified here. It is also known as Thymosin alpha-1, Zadaxin and Thymalfasin.

Regulatory sources checked: . Source verification only; no clinician review is claimed.

Goals

Protocols with this peptide

Educational reference. Figures are illustrative and not a prescription, protocol, or medical advice.

Open in HEIVE