NAD+
Nicotinamide adenine dinucleotide
fatigue
mitochondrial function
energy crashes
mental clarity
oxidative stress
cellular maintenance
metabolic health
sleep
healthspan
neuroprotection
A coenzyme every cell needs to make energy. Levels fall with age, and the entire longevity case rests on putting them back.
Goal profile
ENERGY
4/5 axes
LONGEVITY
5/7 axes
BRAIN
2/8 axes
RECOVERY
1/6 axes
MOOD
1/8 axes
Evidence
1906
first described
73,570
indexed studies
How strong the evidence is
Animal data
Most trials study oral precursors rather than the infusion people actually buy. The ones that measure outcomes instead of blood levels are unconvincing.
Highest study design
animal outcomes
Human studies
14
Replication
several groups, one country
Regulatory status
not approved anywhere
Last reviewed
2026-08-14
The bar is derived from these five facts, not set by hand. Human study counts follow the weekly PubMed refresh; the rest change only when a trial is published or a regulator acts.
How strong the effect is
strength 2 of 5 · weight 0.37
Noticeable but modest
Outcomes are unconvincing — the trials measure blood levels.
What's unique
Not a peptide at all — a coenzyme, and the only item here your cells cannot function without.
Unexpected positive evidence
Infusion work aimed at energy kept reporting alcohol and stimulant cravings dropping.
Benefits
restoration of the central redox cofactor, which falls by roughly half by midlife
Mitochondrial function · immediate
fuel for sirtuin and PARP activity — DNA repair and metabolic signalling
Mitochondrial function · from week 3
better mitochondrial function and cellular energy output
Mitochondrial function · from week 3
clarity, focus, and reduced fatigue reported within days
Mitochondrial function · immediate
support for neuronal resilience and the DNA-damage response
Neuroprotection · from week 8
infusion delivers it directly, bypassing digestion
Mitochondrial function · immediate
Timeline
First sessions
Given too fast it causes chest pressure, nausea and cramping — the drip rate is the whole game. Mental clarity and energy often lift the same day.
Weeks 1–2
The loading phase. Energy, focus and sleep quality improve cumulatively across the first four to six sessions.
Weeks 3–8
Peak window. Stamina and cognitive endurance stabilise. People using it for craving reduction report the strongest effects in this stretch.
Post-course
Tissue levels return to baseline within two to four weeks. Monthly maintenance sessions are the usual pattern after a loading course.
Risks
Short-term
Pushed too fast it causes chest pressure, nausea and cramping. The drip rate is the whole game.
Long-term
Unknown. Whether raising NAD+ feeds an existing tumour is an open and serious question.
Tolerance & withdrawal
None. Loading course, then monthly maintenance, is the common pattern.
Dosing
Dose
10–100 mg subcutaneous; infusions run 250–500 mg per session
50–100 mg subcutaneous is the practical range; infusion doses do not transfer to a shot.
Route
Subcutaneous — abdomen; the burn scales with the push
Push slowly. The burn scales with speed more than with dose, and rushing is what puts people off it.
Timing
Morning; it is stimulating for most people
Early enough that the stimulation does not follow you to bed.
Frequency
2–3× a week, or daily at the low end
Two or three times a week is typical; daily only at the low end.
Cycle
4–8 weeks
Four to eight weeks, then a break to see whether it still does anything.
Duration
Cycled
Run a block, stop, and see whether anything actually changed — that is the only honest test.
Forms
injectable
~100%
+ Full dose delivered; nothing lost to first-pass
− Daily needles, sites, sharps disposal
Refrigerate 2–8 °C after reconstitution
sublingual
5–20%
+ Avoids the stomach; fast onset
− Hold time matters more than people admit
Room temperature, sealed
nasal
Product-specific
+ A needle-free route listed in the source catalog
− Absorption and safety cannot be inferred from the injectable form
Follow the specific product storage instructions
Nasal forms are listed in the source catalog; this does not establish approval, efficacy or equivalent absorption. HEIVE injection calculations do not apply to nasal forms.
topical
Local only
+ Acts where you put it
− No systemic effect worth counting on
Room temperature, away from light
Sources
73,570 indexed papers in the source catalog snapshot; not a live PubMed count
Catalog evidence category: known. This is an editorial classification, not a clinical review.
Community anecdotes do not establish safety or efficacy.
Primary regulatory sources are linked below; clinical literature has not been independently reviewed for this FAQ.
FAQ
NAD+ (Nicotinamide adenine dinucleotide) is a coenzyme (not a peptide). The HEIVE catalog describes it as: A coenzyme every cell needs to make energy. Levels fall with age, and the entire longevity case rests on putting them back. It is also known as Nicotinamide adenine dinucleotide.
Regulatory sources checked: . Source verification only; no clinician review is claimed.