KPV
α-MSH fragment
inflammation
gut healing
immune balance
tissue repair
infection recovery
emotional balance
skin health
The anti-inflammatory tail of α-MSH without the pigmentation activity, studied mostly in colitis models.
Goal profile
RECOVERY
3/6 axes
IMMUNITY
2/4 axes
BEAUTY
1/3 axes
MOOD
1/8 axes
Evidence
1990
first described
114
indexed studies
How strong the evidence is
Animal data
A three-amino-acid tail of a hormone the body already uses to switch inflammation off, which makes the mechanism easy to believe. No trial has tested it in people.
Highest study design
animal outcomes
Human studies
1
Replication
one group only
Regulatory status
not approved anywhere
Last reviewed
2026-08-14
The bar is derived from these five facts, not set by hand. Human study counts follow the weekly PubMed refresh; the rest change only when a trial is published or a regulator acts.
How strong the effect is
strength 2 of 5 · weight 0.32
Noticeable but modest
The mechanism is convincing, the measurements are missing.
What's unique
The anti-inflammatory tail of α-MSH with the pigmentation activity engineered out.
Unexpected positive evidence
Antimicrobial activity against Candida turned up in work on inflammation.
Benefits
the anti-inflammatory core of α-MSH without any pigmentation effect
Inflammation · from week 2
downregulation of NF-κB signalling in gut and skin tissue
Gut healing · from week 3
relief in colitis and inflammatory bowel models
Gut healing · from week 3
faster healing of inflamed or infected wounds
Infection recovery · from week 4
antimicrobial action against Candida and Staphylococcus aureus
Inflammation · from week 2
works both topically and systemically
Inflammation · from week 2
Timeline
Days 1–7
Gut symptoms respond first: less urgency, less cramping, calmer stools. Skin inflammation begins to settle in parallel.
Weeks 2–4
Inflammation drops without the immune suppression that steroids bring. Flare frequency falls, and severity when flares do come is lower.
Weeks 4–8
The steady window. Barrier repair and inflammatory control reinforce each other; most people find the minimum effective dose here.
Post-cycle
Symptoms return over two to four weeks if the trigger — diet, stress, an untreated condition — has not been addressed.
Risks
Short-term
Very few reported. Mild GI upset orally.
Long-term
Unknown beyond a few months of use.
Tolerance & withdrawal
None described.
Dosing
Dose
200–1,000 mcg per injection
Most stay at 250–500 mcg; the top of the range is for gut flares rather than skin.
Route
Subcutaneous, or near the inflamed area; oral and topical also used
Near the inflamed area if it is local; abdomen if it is gut-related.
Timing
Evening
Fits alongside the rest of a night-time routine; for a local problem, dose it when symptoms are worst.
Frequency
Daily
Run it through the flare and stop when it settles, rather than tapering.
Cycle
2–6 weeks
The course tracks the flare rather than a calendar — start when it flares, stop when it settles.
Duration
Flare-driven
It is a flare tool, not maintenance; running it permanently is not how it is used.
Forms
injectable
~100%
+ Full dose delivered; nothing lost to first-pass
− Daily needles, sites, sharps disposal
Refrigerate 2–8 °C after reconstitution
topical
Local only
+ Acts where you put it
− No systemic effect worth counting on
Room temperature, away from light
oral
1–15%
+ Simplest possible routine
− Most of the dose is destroyed before absorption
Cool, dry, dark
Sources
114 indexed papers in the source catalog snapshot; not a live PubMed count
Catalog evidence category: preclinical. This is an editorial classification, not a clinical review.
Community anecdotes do not establish safety or efficacy.
Primary regulatory sources are linked below; clinical literature has not been independently reviewed for this FAQ.
FAQ
KPV (α-MSH fragment) is a tripeptide. The HEIVE catalog describes it as: The anti-inflammatory tail of α-MSH without the pigmentation activity, studied mostly in colitis models. It is also known as α-MSH 11-13 and Lys-Pro-Val.
Regulatory sources checked: . Source verification only; no clinician review is claimed.