Ipamorelin
GH secretagogue
fatigue
sleep
workout energy
tissue repair
training recovery
metabolic health
muscle
fat distribution
body recomposition
keeping the result
bone density
A selective growth-hormone releasing peptide with little effect on cortisol or prolactin.
Goal profile
PERFORMANCE
3/4 axes
WEIGHT
3/5 axes
RECOVERY
3/6 axes
LONGEVITY
3/7 axes
ENERGY
2/5 axes
MOOD
1/8 axes
Evidence
1998
first described
53
indexed studies
How strong the evidence is
Early human data
The growth-hormone pulse is reproducible in humans. The one properly powered outcome trial, in post-operative recovery, missed its endpoint and the programme was dropped.
Highest study design
open-label human use
Human studies
9
Replication
several groups, one country
Regulatory status
not approved anywhere
Last reviewed
2026-08-14
The bar is derived from these five facts, not set by hand. Human study counts follow the weekly PubMed refresh; the rest change only when a trial is published or a regulator acts.
How strong the effect is
strength 2 of 5 · weight 0.39
Noticeable but modest
A reproducible GH pulse, with no outcome behind it.
What's unique
The cleanest of the secretagogues — it lifts growth hormone without dragging cortisol along.
Unexpected positive evidence
Gastric motility improved in studies designed to look only at GH.
Benefits
selective growth-hormone pulses without cortisol, prolactin, or appetite spikes
Fatigue · from week 2
deeper slow-wave sleep, where most natural GH release happens
Fatigue · from week 2
better recovery, lean-mass retention, and connective-tissue repair
Tissue repair · from week 4
gradual visceral-fat reduction with insulin sensitivity preserved
Fat distribution · from week 6
improved skin thickness and nail and hair quality through IGF-1 signalling
Fatigue · from week 2
improved gastric motility and digestive comfort
Fatigue · from week 2
Timeline
Days 1–7
Deeper sleep is the first and most reliable sign, often from the second or third night. Appetite may increase noticeably in the evening.
Weeks 2–4
Recovery between training sessions improves and morning stiffness decreases. Skin and sleep quality change before body composition does.
Weeks 4–12
Recomposition window. Modest fat loss and better muscle fullness accumulate slowly and depend entirely on training and protein intake being in place.
Post-cycle
Growth hormone returns to baseline within 48 hours. Sleep depth fades over a week or two; recomposition holds only if the training does.
Risks
Short-term
Head-rush and hunger in the first 20 minutes; water retention.
Long-term
Sustained GH elevation carries insulin-resistance risk over years.
Tolerance & withdrawal
Receptor desensitisation is real. Five days on, two off is the common pattern.
Dosing
Dose
100–300 mcg per injection, 1–3× a day
200–300 mcg per shot is the common range; more raises cost, not output.
Route
Subcutaneous — abdomen
A shallow belly shot, rotating quadrants so the nightly injection does not build up scar tissue.
Timing
Before bed on an empty stomach; some add a post-workout dose
Food kills the pulse, so eat three hours before. The post-workout dose is a bodybuilding addition, not a requirement.
Frequency
Daily, or 5 on / 2 off on long runs
Daily is standard; two or three shots a day is a bodybuilding pattern, not a general one.
Cycle
8–12 weeks
The pulse pattern needs a couple of months to settle, then a month off keeps the receptor honest.
Duration
Long blocks
Blocks with real breaks, not a permanent nightly habit.
Forms
injectable
~100%
+ Full dose delivered; nothing lost to first-pass
− Daily needles, sites, sharps disposal
Refrigerate 2–8 °C after reconstitution
sublingual
5–20%
+ Avoids the stomach; fast onset
− Hold time matters more than people admit
Room temperature, sealed
Sources
53 indexed papers in the source catalog snapshot; not a live PubMed count
Catalog evidence category: known. This is an editorial classification, not a clinical review.
Community anecdotes do not establish safety or efficacy.
Primary regulatory sources are linked below; clinical literature has not been independently reviewed for this FAQ.
FAQ
Ipamorelin (GH secretagogue) is a pentapeptide. The HEIVE catalog describes it as: A selective growth-hormone releasing peptide with little effect on cortisol or prolactin.
Regulatory sources checked: . Source verification only; no clinician review is claimed.