BPC-157
Body Protection Compound
inflammation
tissue repair
gut healing
training recovery
nerve repair
A synthetic fragment of a protein found in human gastric juice, studied almost entirely in rodents for accelerated soft-tissue healing.
Goal profile
RECOVERY
5/6 axes
Evidence
1991
first described
226
indexed studies
How strong the evidence is
Animal data
Rodent healing data is deep and consistent. Two small human trials in inflammatory bowel disease exist, both from the same group, neither replicated.
Highest study design
animal outcomes
Human studies
2
Replication
one group only
Regulatory status
not approved anywhere
Last reviewed
2026-08-14
The bar is derived from these five facts, not set by hand. Human study counts follow the weekly PubMed refresh; the rest change only when a trial is published or a regulator acts.
How strong the effect is
strength 4 of 5 · weight 0.52
Changes the result
Tissue healing, with a strong signal in animals.
What's unique
It is the only item here that appears to work systemically after oral dosing despite being a peptide.
Unexpected positive evidence
Rodent work repeatedly shows gut-brain effects — reduced anxiety behaviour — that nobody was looking for.
Benefits
accelerated healing of tendon, ligament, muscle, and bone injuries
Tissue repair · immediate
angiogenesis — new vessel growth into damaged and poorly perfused tissue
Tissue repair · from week 3
repair of the gut lining and relief in inflammatory bowel conditions
Gut healing · from week 2
protection of the gastric mucosa against NSAIDs, alcohol, and stress ulceration
Inflammation · immediate
upregulation of VEGF and growth-hormone receptor expression in healing tissue
Tissue repair · from week 3
systemic anti-inflammatory effect that reaches far from the injection site
Inflammation · from week 3
Timeline
Days 1–7
Local pain and stiffness often ease first. Gut symptoms — reflux, cramping, loose stools — tend to settle within the first week. Tendon and joint pain usually feel slightly duller rather than gone.
Weeks 2–4
The healing signal builds. Range of motion improves, older injuries stop flaring after activity, and digestion becomes noticeably more predictable. This is where most people decide it is working.
Weeks 4–8
Peak repair window. Chronic tendon and ligament problems either resolve or clearly plateau — if nothing has changed by week eight, more time rarely helps. Gut lining benefits are usually fully established.
Post-cycle
Structural repair holds; it is real tissue, not a borrowed effect. Gut comfort can drift back over four to six weeks if the underlying cause — diet, alcohol, NSAIDs — is unchanged.
Risks
Short-term
Injection-site irritation; occasional light-headedness in the first week.
Long-term
Unknown. No human study has run past 12 weeks.
Tolerance & withdrawal
No tolerance reported. No withdrawal syndrome described.
Dosing
Dose
200–1,000 mcg per injection
Most settle at 500 mcg and only go higher for an acute injury.
Route
Subcutaneous — abdomen, or near the injury where practical
Near the injury is the folk practice; systemic dosing works either way.
Timing
Evening, or split morning and evening
Evening is the habit because repair overlaps with sleep; morning is fine if it keeps you awake.
Frequency
Daily, or 5 on / 2 off on longer runs
Daily for a short repair block; almost everyone drops to 5/2 past week eight.
Cycle
4–8 weeks, then a break of similar length
People stop when the injury stops complaining, not on a fixed date.
Duration
Course-based
It is a repair tool, not a daily supplement — run it against an injury and stop.
Forms
injectable
~100%
+ Full dose delivered; nothing lost to first-pass
− Daily needles, sites, sharps disposal
Refrigerate 2–8 °C after reconstitution
nasal
Product-specific
+ A needle-free route listed in the source catalog
− Absorption and safety cannot be inferred from the injectable form
Follow the specific product storage instructions
Nasal forms are listed in the source catalog; this does not establish approval, efficacy or equivalent absorption. HEIVE injection calculations do not apply to nasal forms.
topical
Local only
+ Acts where you put it
− No systemic effect worth counting on
Room temperature, away from light
oral
1–15%
+ Simplest possible routine
− Most of the dose is destroyed before absorption
Cool, dry, dark
Sources
226 indexed papers in the source catalog snapshot; not a live PubMed count
Catalog evidence category: preclinical. This is an editorial classification, not a clinical review.
Community anecdotes do not establish safety or efficacy.
Primary regulatory sources are linked below; clinical literature has not been independently reviewed for this FAQ.
FAQ
BPC-157 (Body Protection Compound) is a pentadecapeptide (15 amino acids). The HEIVE catalog describes it as: A synthetic fragment of a protein found in human gastric juice, studied almost entirely in rodents for accelerated soft-tissue healing. It is also known as BPC 157, Body Protection Compound 157 and Pentadecapeptide BPC 157.
Regulatory sources checked: . Source verification only; no clinician review is claimed.