hCG
Human chorionic gonadotropin
hormonal balance
fertility
libido
motivation
muscle
A pregnancy hormone that reads as LH at the testicular receptor. Licensed for fertility and hypogonadism, and the standard way to keep your own production running on testosterone therapy.
Goal profile
SEXUAL
3/4 axes
PERFORMANCE
1/4 axes
MOOD
1/8 axes
Evidence
1927
first described
36,866
indexed studies
How strong the evidence is
Licensed medicine
Ninety years of prescription use in fertility medicine. Its use for restarting a suppressed hormonal axis is off-label and far less studied.
Highest study design
registration trials
Human studies
640
Replication
independent international
Regulatory status
FDA or EMA approval
Last reviewed
2026-08-14
The bar is derived from these five facts, not set by hand. Human study counts follow the weekly PubMed refresh; the rest change only when a trial is published or a regulator acts.
How strong the effect is
strength 4 of 5 · weight 0.80
Changes the result
Restores the axis, and does it reliably.
What's unique
The only item here that restarts your own hormone production instead of replacing it.
Unexpected positive evidence
Mood and motivation scores often move before testosterone does.
Benefits
restart of your own testosterone production rather than replacement
Hormonal balance · immediate
testicular volume and fertility preserved during or after suppression
Hormonal balance · immediate
LH-mimetic signalling that keeps the whole axis running
Hormonal balance · immediate
mood and motivation often move before testosterone numbers do
Motivation · from week 8
recovery of your hormonal axis after suppression
Hormonal balance · immediate
spermatogenesis supported alongside FSH where fertility is the goal
Hormonal balance · immediate
Timeline
Weeks 1–2
Testicular volume starts to recover and morning erections often return first. Mood and motivation frequently shift before any blood marker does.
Weeks 2–6
Testosterone rises toward its own ceiling. Acne, water retention and oestrogen-related symptoms appear here if the dose is too high — this is when bloodwork matters.
Weeks 6–12
Stable window. Fertility markers improve on a slower schedule; sperm parameters take three months to respond because that is how long the cycle takes.
Post-cycle
Output falls back to its pre-hCG baseline over four to six weeks. It restarts your own production rather than replacing it, so stopping means returning to where you started.
Risks
Short-term
Injection-site soreness; acne and water retention as testosterone rises; gynecomastia from aromatisation.
Long-term
Sustained high doses desensitise the Leydig cells. Oestradiol needs measuring, not guessing.
Tolerance & withdrawal
Real at high frequency. Two or three small doses a week beats one large one.
Dosing
Dose
250–1,500 IU per injection
250–500 IU per shot covers testicular support; higher belongs to fertility or restart protocols.
Route
Subcutaneous — abdomen (intramuscular also works)
Subcutaneous is what most use — as effective as intramuscular and easier.
Timing
Any time of day, on the same days each week
The hour is free, the days are not — the point is even spacing across the week.
Frequency
2–3× a week; every other day is the other common pattern
Two or three times a week beats once — the 33-hour half-life leaves gaps otherwise.
Cycle
Continuous alongside testosterone therapy, or 4–6 weeks for a restart
Runs as long as testosterone therapy does; restart blocks are four to six weeks.
Duration
Continuous
It runs as long as the testosterone does; stopping brings back the atrophy it was preventing.
Forms
injectable
~100%
+ Full dose delivered; nothing lost to first-pass
− Daily needles, sites, sharps disposal
Refrigerate 2–8 °C after reconstitution
Sources
36,866 indexed papers in the source catalog snapshot; not a live PubMed count
Catalog evidence category: known. This is an editorial classification, not a clinical review.
Community anecdotes do not establish safety or efficacy.
Primary regulatory sources are linked below; clinical literature has not been independently reviewed for this FAQ.
FAQ
hCG (Human chorionic gonadotropin) is a glycoprotein hormone (not a peptide). The HEIVE catalog describes it as: A pregnancy hormone that reads as LH at the testicular receptor. Licensed for fertility and hypogonadism, and the standard way to keep your own production running on testosterone therapy. It is also known as Human chorionic gonadotropin and Pregnyl.
Regulatory sources checked: . Source verification only; no clinician review is claimed.